Michele Solimena Selected Research

Class 8 Receptor-Like Protein Tyrosine Phosphatases

1/2019	ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor.
8/2016	The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.
3/2015	Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.
1/2008	ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Michele Solimena Research Topics

Disease

12	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2010
11	Insulinoma 01/2020 - 07/2003
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019 - 01/2011
5	Insulin Resistance 01/2022 - 10/2013
3	Neoplasms (Cancer) 01/2015 - 02/2004
2	Chronic Pancreatitis 01/2022 - 07/2011
2	Fibrosis (Cirrhosis) 01/2020 - 10/2013
2	Inflammation (Inflammations) 01/2020 - 10/2013
2	Glucose Intolerance 01/2018 - 01/2015
2	Stiff-Person Syndrome (Stiff Man Syndrome) 02/2011 - 02/2004
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	COVID-19 10/2021
1	Depressive Disorder (Melancholia) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Myocarditis (Carditis) 01/2020
1	Major Depressive Disorder (Major Depressive Disorders) 03/2019
1	Sleep Initiation and Maintenance Disorders (Insomnia) 03/2019
1	Sleep Wake Disorders 03/2019
1	Brain Death (Brain Dead) 01/2019
1	Obesity 12/2018
1	Chronic Disease (Chronic Diseases) 01/2018
1	Virus Diseases (Viral Diseases) 01/2018
1	Hypoglycemia (Reactive Hypoglycemia) 08/2016
1	Pancreatitis 01/2015
1	Cholestasis 01/2015
1	Infections 08/2014
1	Dehydration (Water Stress) 01/2013
1	Hypoxia (Hypoxemia) 09/2011
1	Pancreatic Diseases (Pancreatic Disease) 07/2011
1	Hyperplasia 11/2009
1	Hyperglycemia 11/2008
1	Muscle Rigidity 02/2004
1	Breast Neoplasms (Breast Cancer) 02/2004
1	Rare Diseases (Rare Disease) 02/2004
1	Rhabdomyolysis 02/2004

Drug/Important Bio-Agent (IBA)

14	Insulin (Novolin)FDA Link 12/2021 - 11/2008
7	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 03/2009
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 07/2003
4	Class 8 Receptor-Like Protein Tyrosine PhosphatasesIBA 01/2019 - 01/2008
4	AutoantigensIBA 01/2019 - 07/2003
3	RNA (Ribonucleic Acid)IBA 10/2021 - 01/2020
3	Melatonin Receptors (Melatonin Receptor)IBA 01/2021 - 03/2019
2	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2015
2	Carrier Proteins (Binding Protein)IBA 10/2020 - 03/2009
2	Protein Isoforms (Isoforms)IBA 12/2012 - 02/2004
2	AntigensIBA 01/2011 - 02/2004
1	B-insulinIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 12/2021
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2021
1	ChromatinIBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2021
1	ProinsulinIBA 10/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2020
1	CytokinesIBA 01/2020
1	MT2 Melatonin ReceptorIBA 01/2020
1	Retinaldehyde (Retinal)IBA 03/2019
1	Pharmaceutical PreparationsIBA 03/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	Collagenases (Collagenase)FDA Link 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2019
1	EnzymesIBA 12/2018
1	Actins (F Actin)IBA 08/2016
1	villinIBA 08/2016
1	Protein Tyrosine PhosphatasesIBA 03/2015
1	Tumor Biomarkers (Tumor Markers)IBA 01/2015
1	Anaphylatoxin C5a ReceptorIBA 10/2013
1	Complement System Proteins (Complement)IBA 10/2013
1	Interleukin-10 (Interleukin 10)IBA 10/2013
1	Ethanol (Ethyl Alcohol)IBA 01/2013
1	Xylenes (Xylene)IBA 01/2013
1	IceIBA 01/2013
1	Indicators and Reagents (Reagents)IBA 01/2013
1	3,5-diisopropylsalicylic acid (DIPS)IBA 01/2013
1	Transcription Factors (Transcription Factor)IBA 05/2012
1	Oxygen (Dioxygen)IBA 09/2011
1	Immunoglobulin G (IgG)IBA 02/2011
1	Messenger RNA (mRNA)IBA 03/2009
1	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)IBA 03/2009
1	Monomeric GTP-Binding ProteinsIBA 04/2008
1	Coat Protein Complex I (COPI)IBA 04/2008
1	Cyclin D1IBA 01/2008
1	AntibodiesIBA 02/2004
1	amphiphysinIBA 02/2004

Therapy/Procedure

3	Lasers (Laser) 01/2019 - 01/2013
2	Transplantation 10/2017 - 09/2011
2	Pancreatectomy 01/2015 - 07/2011
1	Pancreaticoduodenectomy 01/2022
1	Therapeutics 01/2020
1	Immunotherapy 02/2004